Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical MedicineAuthor:
Publisher: CRC Press
Publish date: February 1992
Describes cellular calcium transport in terms of entry, intracellular calcium handling, and extrusion Analyzes the role of calbindins and focuses on the gene calbindin D-9K and its expression Discusses hormonal control, including the novel chromogranin protein family and the PTH/PTH-related peptide Explores the newest concepts of osteoclast regulation and the mechanism by which phosphate translocation participates in bone formation Examines metabolic bone diseases, specifically primary and secondary osteoporosis, and their treatment and discusses the effects of drugs on the skeletal system Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine presents thinking and front-line research addressing calcium and phosphate homeostasis and related clinical problems. Major topics include calcium and phosphate transport in the mammalian body and some of its defects, several aspects of hormonal control of calcium and phosphorus metabolism, including PTH-related peptide, and basic and clinical aspects of bone and bone diseases. Other topics include calcium entry and extrusion mechanisms, secondary osteoporosis, how bone cells translocate phosphate needed to bone mineral, and the culture of renal and intestinal cells capable of transporting calcium in vitro. The book also features two prize-winning contributions, one deals with the characterization of a major calcium transport protein, calbindin D-9K, while the other discusses how the osteoclast, the bone-resorbing cell, is feedback-regulated. Extra- and Intracellular Calcium and Phosphate Regulation: From Basic Research to Clinical Medicine provides plenty of useful information for basic and clinical scientists alike, including biochemists, physiologists, cell biologists, pharmacologists, internists, orthopedic surgeons, dentists, and pathologists.