Thiamine: Catalytic Mechanisms in Normal and Disease StatesAuthor:
Publisher: CRC Press
Publish date: November 2003
Provides new features of the structure and mechanisms in yeast pyruvate decarboxylase Discusses new perspectives on the cellular role of thiamine triphosphate and thiamine triphosphatase Covers physiological effects of replacing the PDH complex of E. coli by genetically engineered variants or by pyruvate oxidase Presents new insights into neurogenerative diseases Thiamine: Catalytic Mechanisms in Normal and Disease States brings together the most recent developments in thiamine diphosphate (TDP)-requiring enzyme research and details the mechanisms of catalysis and structure-function relationships, as well as pathophysiological aspects of a spectrum of diseases associated with TDP-requiring enzymes. Providing new insights into neurogenerative diseases, this volume associates defects in the function of TDP-dependent enzymes with numerous metabolic disorders and disease states and offers novel aspects of thiamine enzymes in chiral synthesis as well as new perspectives on the cellular role of thiamine triphosphate and thiamine triphosphates.